La siguiente información se refiere a la investigación y los ensayos clínicos actuales que pueden ser de interés para quienes tratan a personas con trastornos neurológicos.

Becas

  • SMHS Center for Faculty Excellence, Virtual Reality to Enhance Gross Anatomy Education in Graduate and Medical Student Programs, 2019 - 2021, total de la adjudicación: $9,990 (Investigador principal: Sherman, investigador principal adjunto: Brown)
  • Plasma Medicine Initiative, US Patent Innovations Inc., 2017 - 2022, total de la adjudicación: $5.3 millones (Investigador principal: Keidar, investigador principal adjunto: Sherman)
  • National Science Foundation (NSF), Industry University Cooperative Research Centers (IUCRC), 2018 - 2023, Center for High Pressure Plasma Energy, Agriculture, and Biomedical Technologies (PEAB), $750,000 (NSF), (Investigador principal: Keidar, investigador principal adjunto: Sherman)
  • GW Institute for Biomedical Engineering Interdisciplinary Research Fund, Cold Atmospheric Plasma as a Novel Therapeutic Approach for Glioblastoma, Examine the Therapeutic Potential of CAP for Cancer Treatment in a Xenograft Murine Model of GBM, 2015 - 2016, subsidio: $20,000
  • Katzen Cancer Research Center Innovative Cancer Pilot Research Study Grant, Cold Atmospheric Plasma in the Treatment of Malignant Glioma, 2013, subsidio: $60,000

Ensayos clínicos patrocinados

  • National Institutes of Health (NIH/NIMHD) U54 African American Cardiovascular Pharmacogenetic Consortium (ACCOuNT), subadjudicación: "Comparative Analysis of Platelet Genomics in European- and African-Americans with Thrombotic Disease," investigador principal: Travis O'Brien
  • Randomized, Multi-center, Phase 2 Study of DSP-7888 in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma Following Initial Therapy, Enrolling
  • Multi-center Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignancy in Patients with Newly Diagnosed or Recurrent Malignant Glioma: A Safety, Histopathology, and Correlative Biomarker Study, marzo de 2018 - enero de 2019
  • A071401: Meningioma (Alliance): Phase II Trial of Smo/AKT/NF2 Inhibitors in Progressive Meningiomas with SMO/AKT/NF2 Mutations
  • BBI-DSP7888-20G: A Randomized, Multi-center, Phase 2 Study of DSP-7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma Following Initial Therapy
  • GWIRB #121624: 5ALA: A Multi-center Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor in Patients with Newly Diagnosed or Recurrent Malignant Gliomas: A Safety, Histopathology, and Correlative Biomarker Study
  • GWIRB #040855: HUD: Codman Enterprise Vascular Reconstruction Device and Delivery System
  • GWIRB #031437: HUD: Wingspan Stent System with Gateway PTA Balloon Catheter
  • GWIRB #111239: Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)
  • GWIRB #51810: Multi-institutional Study Assessing Pediatric and Adult Chiari 1 Malformation Surgery
  • GWIRB #101421: HUD: Deep Brain Stimulation for Treatment Resistant Dystonia
  • GWIRB #04855: HUD: Neuroform Atlas Stent
  • GWIRB #031437: HUD: Wingspan Stent System with Gateway PTA Balloon Catheter
  • Invest Feasibility: A Single Arm, Feasibility Study of Minimally Invasive Endoscopic Surgical Treatment with Apollo/Artemis for in Supratentorial Intracerebral Hemorrhage (ICH)
  • Invest Registry: Minimally Invasive Endoscopic Surgical Treatment with Apollo/Artemis in Patients with Brain Hemorrhage: A Prospective Multi-center Registry
  • A Prospective, Multi-center Study of Artemis, a Minimally Invasive Neuro Evacuation Device, in the Removal of Intracerebral Hemorrhage

Ensayos iniciados por investigadores

  • Neuro-oncology Tumor Specimen Bank, julio de 2012 al presente
  • Neuro-oncology Registry, julio de 2012 al presente
  • Role of FoxJ1 in the Treatment of Glioblastoma, marzo de 2016 - junio de 2018

Investigación

The George Washington University
Invierno de 2019 al presente
Investigación conjunta con Kirsten Brown, PhD
Investigación enfocada en descubrir el rol de la realidad virtual en la mejora de la educación sobre la anatomía macroscópica en los programas para estudiantes y graduados de medicina.

The George Washington University
Primavera de 2017 al presente
Investigación conjunta con Ramin Javan, MD, Keith Mortman, MD y Neil Sikka, MD
Desarrollo de un Instituto de Innovaciones de The George Washington University.

The George Washington University y Departamento de Defensa
Primavera de 2018 al presente
Investigación conjunta con James Hahn, PhD
Desarrollo de un simulador económico, versátil y portátil de respuesta hepática.

The George Washington University
Primavera de 2012 al presente
Investigación conjunta con Michael Keidar, PhD
Investigación del uso de tecnología de plasma atmosférico frío en el tratamiento de gliomas malignos.


Proyectos anteriores

  • Assessment of Brain Tumor Tissue Oxygenation Levels in Patients with Malignant Glial Neoplasms, julio de 2012 - junio de 2015
  • Assessment of Recurrent Metastatic Cancer Using Cold Atmospheric Plasma, mayo de 2016 - diciembre de 2017
  • Phase 3, Randomized, Controlled, Double-Arm, Open-Label, Multi-center Study of VB-111 Combined with Bevacizumab vs. Bevacizumab Monotherapy in Patients with Recurrent Glioblastoma, junio de 2016 - diciembre de 2016
  • Phase 1/2 Study of SL-701, a Subcutaneously Injected Multivalent Glioma - Associated Antigen Vaccine, in Adult Patients with Recurrent Glioblastoma, Protocol STML-701-0114, septiembre de 2014 - septiembre de 2016
  • Duraseal Exact Spine Sealant System Post-Approval Study, Protocol COV-DRSS-0002, February 2012 – December 2015
  • Open-label Phase 1/2 (Safety Lead-in) Study of Trans Sodium Crocetinate (TSC) with Concomitant Treatment of Fractionated Radiation Therapy and Temozolomide in Newly Diagnosed Glioblastoma Patients to Evaluate Safety and Efficacy, Protocol 100-202, febrero de 2012 - junio de 2013
  • The George Washington University, Department of Pharmacology and Physiology, Research in Conjunction with Anthony LaMantia, PhD, Characterization of the Forkhead Gene FOXJ1 as a Biomarker in Glioblastoma​, primavera de 2011 - primavera de 2018
  • The George Washington University and Children's National Medical Center, Research in Conjunction with Javad Nazarian, Researching the Role of FoxJ1 as a Biomarker in DIPG​, otoño de 2017 - primavera de 2018
  • The George Washington University, Neurosurgery Department, Research in Conjunction with Dr. Michael Keidar, Research Analyzing Excitation and Control of Neural Fiber Activity in a Weak Non-thermal Microwave Field, invierno de 2015 - primavera de 2018
  • The George Washington University, Department of Pharmacology and Physiology, Research in Conjunction with Dr. Anthony LaMantia and Dr. Sally Moody, Characterization of Neural Precursor Cells in Glioblastoma: Developing New Treatment Targets, primavera de 2011 - primavera de 2018
  • The George Washington University, Department of Pharmacology and Physiology, Research in Conjunction with Dr. Anthony LaMantia and Dr. Sally Moody, Researching the Role of FoxD4 on Murine Neuronal Differentiation, otoño de 2011 - otoño de 2017
  • The George Washington University, Neurosurgery Department, Research in Conjunction with Dr. Ferid Murad, Researching the Effects of Combination Phospohdiesterase-5 Inhibitor and Brain Naturetic Peptide on Glioma Progression, otoño de 2011 - primavera de 2012